About this test

What is this test for?

Assessing active B12 helps detect early or functional deficiency that may not be apparent on total B12 testing alone. Results guide supplementation decisions and further investigation where neurological or haematological symptoms are present.


What does this test measure?

This test measures holotranscobalamin, often referred to as “active B12.” Unlike total B12, which reflects all circulating forms, active B12 represents the fraction that is biologically available for use by cells. It plays a crucial role in nerve function, DNA synthesis, and red blood cell production.


When is this test recommended?

Active B12 testing may be recommended when symptoms such as persistent fatigue, tingling in the hands or feet, memory changes, or unexplained anaemia are present. It can also be requested in individuals with dietary restriction, gastrointestinal disorders affecting absorption, or those taking medications that may interfere with B12 uptake.


What’s included in this test

Vitamins
Vitamin B12 (Active)
Active Vitamin B12 measures the biologically available form of B12 that your body can actually use. It's key for energy, nerve health, and mental clarity.

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